salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis
نویسندگان
چکیده
background: infl ammatory cytokines such as interleukin-6 (il-6) and tumor necrosis factor-alpha (tnf-α) are elevated in end-stage renal disease (esrd). il-6 and tnf-α are toxins which deteriorate renal function, and their pathogenic role has been confi rmed in cardiovascular and oral diseases. this study was designed to investigate the salivary levels of il-6 and tnf-α in patients with esrd undergoing hemodialysis (hd). materials and methods: twenty patients with esrd who were treated with 4 h hd sessions, with low fl ux membrane were included in this cross-sectional study. average kt/v index in patients was 1.19 ± 0.1. twenty age-sex-matched healthy controls with no infectious diseases during 1 month before saliva sampling were selected. unstimulated whole saliva was collected and tnf-α and il-6, concentrations were measured using human il-6 and tnf-α elisa kits. independent t-test was used to analyze the data using spss (α = 0.05). results: there was a signifi cant difference between dialysis and control groups regarding the salivary levels of tnf-α (p = 0.034) and il-6 (p = 0.001). conclusion: considering the results of this study and reported role of infl ammatory cytokines in the pathogenesis of cardiovascular and oral diseases, measurement of salivary il-6 and tnf-α in hd patients may help in risk stratifi cation of hd patients and in planning pertinent preventive strategies. key words: cytokine, hemodialysis, renal failure, saliva
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عنوان ژورنال:
dental research journalجلد ۱۳، شماره ۱، صفحات ۰-۰
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